Adult GH deficiency - the value of IGF-I estimation
نویسندگان
چکیده
منابع مشابه
The GH/IGF-I axis and longevity.
Several converging lines of evidence obtained over the last years in a wide variety of experimental model organisms suggest that the ageing process is regulated by genes that encode proteins from the somatotroph axis: longevity genes like daf-2, which were identified using mutant Caenorhabditis elegans strains, turned out to be orthologues of the mammalian genes encoding insulin-like signalling...
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Context Autosomal-recessive mutations in the growth hormone receptor (GHR) are the most common causes for primary growth hormone insensitivity (GHI) syndrome with classical GHI phenotypically characterized by severe short stature and marked insulin-like growth factor (IGF)-I deficiency. We report three families with dominant-negative heterozygous mutations in the intracellular domain of the GHR...
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Growth hormone (GH), the main regulator for post-natal growth, has important metabolic actions on different tissues, similar or opposite to insulin like growth factor I (IGF-I), mainly produced by the liver after the binding of GH to its receptor. Experiments with animal models indicate an important role of GH on insulin resistance although the IGF-I role is not yet completely established. In h...
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The development of sensitive and specific growth hormone (GH) and insulin-like growth factor I (IGF-I) assays opened a new page in the diagnosis and surveillance of acromegaly. Currently, it is possible to make an accurate pre-operative diagnosis even in patients with virtually no typical clinical signs of the disease and to monitor the efficacy of therapeutic intervention with a high degree of...
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The growth hormone/insulin-like growth factor I (GH/IGF-I) axis is an important regulator of brain function which view is based on the evidence that 1) GH and IGF-I can cross the blood brain barrier, 2) GH and IGF-I can bind to sites in various brain structures, including the hippocampus, 3) GH can alter the dopamine turnover in the hippocampus and IGF-I the acetylcholine release, and 4) GH and...
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ژورنال
عنوان ژورنال: Reviews in Endocrinology and Metabolism
سال: 2013
ISSN: 2282-8362
DOI: 10.11138/rem/2013.1.2.067